XenoTech: Uncommon Science, Uncommon Service
XenoTech is dedicated to providing the highest quality GLP in vitro drug metabolism and drug-drug interaction studies to pharmaceutical and chemical companies worldwide.
We are the leading provider of a variety of in vitro tools including hepatocytes, microsomes, S9 fraction, recombinant CYPs, transporter membranes, substrates and metabolites and antibodies against Cytochromes P450.
Selected Frequently Asked Questions
How do you prepare your cryopreserved hepatocytes?
The liver tissue is perfused and the cells are isolated. Percoll® centrifugation is performed to improve the cell viability. Finally, the cells are cryopreserved as described in our manuscript: "Effect of cryopreservation on cytochrome P450 enzyme induction in cultured rat hepatocytes," A Madan, R DeHaan, D Mudra, K Carroll, E LeCluyse and A Parkinson, Drug Metab Dispos, 27:327-335, 1999.
How are cryopreserved hepatocytes shipped?
The hepatocytes are shipped in a "dry dewar." This is a cryogenic shipper containing vapor phase liquid nitrogen. The containers include a return airbill for easy return to XenoTech.
Can I order pooled human hepatocytes?
XenoTech offers individual human hepatocytes in a “Pooling Category.” Each vial has an assured minimum viable yield of 1.0 x 106 cells based on post-thaw data. This provides a cost-effective method for purchasing several different individuals human vials, which can be pooled upon thawing.