Cryopreserved Human Hepatocytes For Induction

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PackagingCharacterization Provided

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XenoTech routinely checks each lot of cyropreserved human hepatocytes to ascertain their ability to attach to collagen substratum and to respond to the prototypical inducers, omeprazole and rifampin. Each lot that meets our performance criteria is characterized to determine fold induction of CYP1A2 and 3A4.

A photomicrograph of the plated cells, taken prior to treatment, is featured on each datasheet; an example from a representative lot is shown here.

Packaging

XenoTech's cryopreserved human hepatocytes are available in Assured Minimum Yield (AMY) Categories, so you can choose the number of viable cells that you need for your experiment.

*Vial size is 1.5 mL

Characterization Provided

Induction data from a representative lot of H1000.H15+

* Refers to the increase in pmol metabolite formed when compared to control.

We recommend the use of supplemented Modified Chee’s Medium (K2300) with all cultured hepatocytes for overlay, feeding and dosing.

Additional characterization provided:

    •    % Viability
    •    Phenacetin O-dealkylation
    •    Coumarin 7-hydroxylation
    •    Bupropion hydroxylation
    •    Amodiaquine N-dealkylation
    •    Diclofenac 4'-hydroxylation
    •    S-Mephenytoin 4'-hydroxylation
    •    Dextromethorphan O-demethylation
    •    Chlorzoxazone 6-hydroxylation
    •    Testosterone 6β-hydroxylation
    •    Midazolam 1'-hydroxylation

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