IGS Sprague-Dawley Rat Lung Subcellular Fractions

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As the primary site for the entrance of airborne agents, and as the recipient of all cardiac output, the lungs may provide both first-pass and systemic metabolism of xenobiotics through several enzymatic pathways including both cytochrome P450 and Phase 2 enzymes.

Packaging

Micro­somes
Concentration: 10 mg/mL
Suspension buffer: 250 mM sucrose

S9 fraction
Concentration: 5 mg/mL
Suspension buffer: 50 mM TRIS·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA

Characterization Provided

XenoTech’s lung subcellular fractions are characterized for the following activities:

• NADPH-cytochrome c reductase
• 7-Ethoxyresorufin O-dealkylation
• 4-Methylumbelliferone glucuronidation

Product Details

NOMENCLATURE Crl:CD (SD)IGS BR ORIGIN Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. To CRL in 1950 from Sprague Dawley, Inc. Caesarean rederived in 1955 from original Charles River Sprague Dawley® colonies. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Rederived into isolator foundation colony in 1997. IGS refers to animals bred using the CRL International Genetic Standard system. COAT COLOR Albino.

Related Products

XenoTech also offers subcellular fractions of pulmonary tissue from the following toxicologically significant species:

• Human
• Cynomolgus monkey
• Beagle dog

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