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Calendar of Events
| Date | Event Name |
|---|---|
| Sep 4 - 8, 2010 | ISSX EU Meeting |
| Sep 13 - 17, 2010 | Land O'Lakes Drug Metabolism |
| Nov 14 - 18, 2010 | AAPS 2010 |
Beagle Dog Treated Subcellular Fractions
XenoTech provides hepatic subcellular fractions from sexually-mature, male Beagle dogs treated with prototypical inducers to serve as positive controls for ex vivo enzyme induction studies.
These products are pooled from many animals to ensure good representation of the inducer and to provide sufficient product availability. The following lot-specific product information is included with each order of microsomes.
• Specific content of cytochrome P450
• Specific content of cytochrome b5
• NADPH-cytochrome c reductase activity
• Activity of the inducible CYP enzyme
• Dosing regimen
• Animal husbandry conditions
Induction of specific cytochrome P450 enzymes are obtained through the treatment of dogs with the following prototypical inducers.
• β-Naphthoflavone
• Phenobarbital
• Rifampin
• Clofibric acid
• Saline (control)
• Corn oil (control)
Products
| Product # | Name | Gender | Amount | Induced CYP Control |
| D1063 | Microsomes from Clofibric acid-treated Beagle Dogs | Male | 0.5 mL at 20 mg/mL | CYP4A |
| D1073 | Microsomes from Saline-treated Beagle Dogs | Male | 0.5 mL at 20 mg/mL | Vehicle Control |
| D1078 | Microsomes from Phenobarbital-treated Beagle Dogs | Male | 0.5 mL at 20 mg/mL | CYP2B |
| D1083 | Microsomes from b-Naphthoflavone-treated Beagle Dogs | Male | 0.5 mL at 20 mg/mL | CYP1A |
| D1095 | Microsomes from Rifampin-treated Beagle Dogs | Male | 0.5 mL at 20 mg/mL | CYP3A |
| D1098 | Microsomes from Corn oil-treated Beagle Dogs | Male | 0.5 mL at 20 mg/mL | Vehicle Control |
