Enzyme Induction

Enzyme induction can increase the metabolic clearance of a concomitantly administered drug, resulting in reduced efficacy, which may comprise the therapeutic effectiveness of a drug. As such, the FDA and other regulatory agencies recognize enzyme induction as a potential cause of drug-drug interactions. 

XenoTech's induction studies assess the potential for a drug candidate to induce (up-regulate) the expression of drug-metabolizing enzymes. Our studies can be divided into two major categories:

In Vitro studies evaluate the enzyme induction potential of a drug candidate in primary cultures of human hepatocytes.

Ex Vivo studies are performed with liver microsomes from treated animals, comparing enzymatic activities against suitable positive controls.

Download XenoTech's Enzyme Induction Informational Flyer Here!