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Enzyme induction can increase the metabolic clearance of a concomitantly administered drug, resulting in reduced efficacy, which may comprise the therapeutic effectiveness of a drug. As such, the FDA and other regulatory agencies recognize enzyme induction as a potential cause of drug-drug interactions.
XenoTech's induction studies assess the potential for a drug candidate to induce (up-regulate) the expression of drug-metabolizing enzymes. Our studies can be divided into two major categories:
In Vitro studies evaluate the enzyme induction potential of a drug candidate in primary cultures of human hepatocytes.
Ex Vivo studies are performed with liver microsomes from treated animals, comparing enzymatic activities against suitable positive controls.