Services
- Analytical Services
- Biologic DDIs
- Drug Metabolism
- Drug Transporters
- Enzyme Induction
- Enzyme Inhibition
- Hepatotoxicity
- In Vivo ADME
- Lysosomal Trapping
- Regulatory Compliance
- Technology Support
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Calendar of Events
| Date | Event Name |
|---|---|
| May 26 - 28, 2013 | DDI Marbach Castle Conference |
Ex Vivo Enzyme Induction
Assay SelectionTest SystemAutomation and AnalysisInducers
Studies of ex vivo induction in the rat, mouse, dog or monkey can provide valuable information to the investigation of a drug candidate. Not only are these types of induction studies cost-effective, they can provide the following information to your investigation:
- Which prototypical CYP inducers the drug candidate resembles
- Epigenetic tumor formation
- Which species most closely resembles human
- Drug-drug interactions
- Pharmacokinetic tolerance
- Increased elimination (auto-induction)
Assay Selection
CYP1A 7-Ethoxyresorufin O-dealkylation
CYP2A6 Coumarin 7-hydroxylation
CYP2B Resorufin O-dealkylation
CYP2B Testosterone oxidation
CYP2C Testosterone oxidation
CYP2D6 Dextromethorphan O-demethylation
CYP2E1 Chlorzoxazone 6-hydroxylation
CYP2E1 4-Nitrophenol hydroxylation
CYP3A Testosterone oxidation
CYP4A Lauric acid hydroxylation
Western blot analysis
Test System
Microsomes prepared from treated tissue.
Automation and Analysis
Tecan liquid-handling system
Validated LC/MS/MS methods
High-throughput Shimadzu autosamplers
Deuterated internal standards
Inducers
β-naphthoflavone
phenobarbital
isoniazid
dexamethasone
rifampin
clofibric acid
